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Induction of anti-mRBC autoimmunity in mice. Mice were sensitized with rRBCs and anti-CD25 every week for three weeks. The degree of RBC IgG sensitization (a) and the reticulocyte counts (b) were then quantified periodically by flow cytometry (n = 4 for naïve, 15 for sensitized; mean + SEM). *p < 0.05, ****p < 0.0001; Student’s t-test.
