Table 1.

Published medical literature estimating tumor doubling times.

Study	Method of Estimation	n	Td (days) Median	Td (days) Range
Gershon-Cohen, 1963 Cancer	Mammography	18	—	23–209
Kusama, Cancer 1972	Metastases	199	105	6–548
Charlson, JAMA 1974	History	219	—	—
Pearlman, Cancer 1976	Mastectomy Scar Local Recurrence	82	—	2–140
Shackney, Ann Intern Med 1978	Mastectomy Scar Local Recurrence	243	25, 129*	3–500+
Von Fournier, Cancer 1980	Mammography	147	212**	44–1,869
Arnerlöv, Cancer 1992	Mammography	158	180	18–270
Spratt, Cancer 1993	Mammography	448	260	10–7,051
Tilanus-Linthorst, Eur J Cancer 2005	Imaging	25	84 BRCA−	~15–450
	Imaging	30	45 BRCA+
Weedon-Fekjær, Br Cancer Res 2008	Mammography	364,731	§1.7 years	—
Summary		18 – 364,731	45 – 260	2 – 7051

Td = Tumor doubling time

^*Early stage, late stage cancers

^**Mean

^§Time to increase: 1.0 cm to 2.0 cm, not a true doubling time