Table 4:
Association of eGFR and incident VTE with adjustment for biomarkers of procoagulation and inflammation
| Model | HR (95% CI) of VTE per 10-unit lower eGFR | HR (95% CI) of VTE by quartile of eGFR (ml/min/1.73m2) | |||
|---|---|---|---|---|---|
| Q1 (7-≤71) | Q2 (>71-≤87) | Q3 (>87-≤103) | Q4 (>103–107) | ||
| Case-Cohort Study | |||||
| Cases (n) | 66 | 74 | 60 | 47 | |
| Cohort sample (n) | 233 | 225 | 239 | 252 | |
| Base Model* | 1.13 (1.02, 1.25) | 1.39 (0.77, 2.49) | 1.19 (0.71, 2.01) | 1.06 (0.65, 1.74) | 1.0 |
| Base Model + D-dimer | 1.10 (0.99, 1.21) | 1.12 (0.62, 2.05) | 1.11 (0.65, 1.91) | 1.06 (0.64, 1.76) | 1.0 |
| Base Model + FVIII | 0.98 (0.87, 1.11) | 0.69 (0.35, 1.37) | 0.60 (0.32, 1.11) | 0.86 (0.50, 1.48) | 1.0 |
| Base Model + CRP | 1.11 (1.00, 1.22) | 1.24 (0.68, 2.24) | 1.15 (0.69, 1.94) | 1.03 (0.63, 1.69) | 1.0 |
| Full Cohort | |||||
| Base Model | 1.09 (1.02, 1.16) | 1.46 (0.91, 2.36) | 1.13 (0.72, 1.80) | 0.97 (0.61, 1.54) | 1.0 |
| Base Model + CRP | 1.07 (1.00, 1.15) | 1.36 (0.84, 2.19) | 1.09 (0.69, 1.72) | 0.96 (0.60, 1.52) | 1.0 |
Abbreviations: HR, hazard ratio; CI, confidence interval; Q, quartile; FVIII, Factor VIII; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate. eGFR as a predictor is presented as a continuous variable (HR per 10 ml/min/1.73m2 decrement) and as quartiles with reference group as the highest quartile of eGFR. Cox models were adjusted for age, sex, race, region, race*region and BMI (Base Model*) and biomarkers individually. D-dimer and CRP were log transformed.