Table 5:
The association of lifestyle factors and medications with the risk of VTE, stratified by CKD status
| HR (95% CI) of VTE | P interaction of Protective Factor × CKD Status | ||||
|---|---|---|---|---|---|
| Overall (n = 25,936) | CKD (n = 2,473) | No CKD (n = 23,463) | |||
| Regular Aspirin Use | N cases | 124 | 22 | 102 | |
| N non-cases | 11,059 | 1,341 | 9,718 | ||
| 1.08 (0.81, 1.43) | 0.96 (0.51, 1.79) | 1.07 (0.80, 1.41) | 0.64 | ||
| Statin Use | N cases | 70 | 16 | 54 | |
| N non-cases | 8,005 | 1,078 | 6,927 | ||
| 0.68 (0.50, 0.93) | 0.86 (0.46, 1.64) | 0.67 (0.49, 0.93) | 0.61 | ||
| Warfarin Use | N cases | 4 | 2 | 2 | |
| N non-cases | 704 | 177 | 527 | ||
| 0.30 (0.07, 1.21) | 0.70 (0.17, 2.94) | 0.29 (0.07, 1.19) | 0.41 | ||
| Physical activity 1-3 ×/week vs none | N cases | 83 | 12 | 71 | 0.98 |
| N non-cases | 9,214 | 700 | 8,514 | ||
| 0.82 (0.59, 1.14) | 0.88 (0.43, 1.81) | 0.82 (0.59, 1.14) | |||
| Physical activity 4+/week vs none | N cases | 66 | 8 | 58 | |
| N non-cases | 7,622 | 539 | 7,083 | ||
| 0.76 (0.53, 1.07) | 0.73 (0.32, 1.67) | 0.76 (0.53, 1.08) | |||
| BMI<25 vs ≥25 | N cases | 41 | 10 | 31 | |
| N non-cases | 6,410 | 545 | 5,865 | ||
| 0.48 (0.32, 0.70) | 1.07 (0.51, 2.22) | 0.47 (0.32, 0.70) | 0.07 | ||
CKD is defined as eGFR < 60 ml/min/1.73m2. Models were adjusted for age, sex, race, region, race*region, BMI.