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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Semin Cancer Biol. 2018 Mar 5;54:162–173. doi: 10.1016/j.semcancer.2018.02.008

Table 2.

Equilibrium dissociation constants (KD) for RAS effectors. KD = kd,eff/ka,eff as in Fig. 1. Values have units of μM. A dash indicates that no value for the isoform was reported in the cited study

Effector HRAS NRAS KRAS Reference
CRAF 0.094 0.048 0.142 [160]
RASSF5 0.238 0.442 0.421
RALGDS 2.5 2.84 1.39
PLCE1 3.7 5.36 8.9
PIK3CA 84.3 145 204.7
PIK3CG - 2.9 -
RASSF1 39 - -
MLLT4 17.8 - - [182]
RGL1 1.73 - - [183]
ARAF 0.81 - -
RGS14 14 - -
RIN1 0.8 - -
BRAF 0.04 - -