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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Addict Biol. 2018 Mar 5;24(3):485–497. doi: 10.1111/adb.12615

Figure 2.

Figure 2

Cocaine self-administration behavior showing escalation of drug in take. Panel A shows the mean number of infusions (0 or 1mg/kg cocaine) animals received during acquisition (grey shaded area) and escalation period. Data points represent 3 day averages (mean ± s.e.); * indicates significant difference from saline administering animals. Panel B shows the number of infusions at the start (circle) and end (triangle) of the escalation period for each animal; these points are highlighted in yellow on panel A. Panel C shows infusions during the first hour at the start and end of the escalation period; * indicates significant difference from the start, # indicates difference from short access. This shows significant escalation of drug intake in the LgA group.