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. 2018 Aug 29;9:2058. doi: 10.3389/fmicb.2018.02058

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Copyright © 2018 Graf, Zieringer, Haas, Nieß, Blombach and Takors.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Illustration of percentage amino acid (AA)-biomass yields (mmol g^-1) calculated from AA supplementation experiments in relation to the mean AA-composition of biomass from different C. glutamicum strains (cf. Table 4). AA-amounts consumed during the experiments which were higher (above 100%) or lower (below 100%) than the published values are highlighted in yellow and red, respectively. (B) Results of the sensitivity analyses indicating the impact of AA-uptake on the growth rate of the in silico cell (cf. Eq. 8). The experimental biomass-glucose yield (Y_XGlc) observed for the strain grown in CGXII [4% (w/v) glucose, Table 2] is given as reference. Color-coding is adapted from panel (A). (C) Results of unbound AA-uptake (q_max,AA) by the in silico cell. The experimental glucose consumption rate (q_Glc) observed for growth in CGXII [4% (w/v) glucose, Table 2] is given as reference. Color-coding is adapted from panel (A).