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. 2018 Aug 29;9:977. doi: 10.3389/fphar.2018.00977

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Copyright © 2018 Chen, Lai, Hung, Lin, Huang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of PIO on I_K(M) amplitude in mHippoE-14 hippocampal neurons. These experiments were conducted in cells bathed in high K⁺, Ca²⁺-free solution and the recording pipette was filled with K⁺-containing solution. (A) Superimposed I_K(M) traces obtained in the absence (a) and presence of 3 μM (b), and 10 μM PIO (c). The upper part indicates the voltage protocol used. (B) Bar graph showing the effect of PIO, linopirdine, and PIO plus flupirtine on I_K(M) amplitude (mean ± SEM; n = 9–11 for each bar). The I_K(M) amplitude elicited by membrane depolarization from –50 to –10 mV was measured. (a) Control; (b) 10 μM PIO; (c) 10 μM linopirdine; (d) 10 μM PIO plus 10 μM flupirtine. ^∗Significantly different from control (P < 0.05) and ^∗∗significantly different from PIO (10 μM) alone group (P < 0.05). LINO, linopirdine; FLUP, flupirtine.