Table 1.
Biometric and vascular parameters of the femoral artery in normotensive Wistar-Kyoto (WKY) and borderline hypertensive rats (BHR).
| WKY |
BHR |
|||||||
|---|---|---|---|---|---|---|---|---|
| C7 | Stress | C9 | Post | C7 | Stress | C9 | Post | |
| n = 6–8 | n = 8–10 | n = 6–8 | n = 8–10 | n = 6–8 | n = 8–10 | n = 6–8 | n = 8–10 | |
| ND (μm) | 649 ± 17 | 637 ± 16 | 681 ± 16 | 691 ± 10# | 677 ± 19 | 659 ± 15 | 690 ± 11 | 708 ± 11# |
| Emax ACh (%) | 87 ± 2 | 90 ± 2 | 84 ± 2 | 84 ± 4 | 81 ± 3 | 80 ± 4 | 83 ± 2 | 83 ± 3 |
| Emax SNP (%) | 95 ± 1 | 97 ± 1 | 97 ± 1 | 97 ± 1 | 97 ± 1 | 99 ± 1 | 97 ± 1 | 96 ± 2 |
| NAp (μN/mm) | 518 ± 78 | 621 ± 48 | 872 ± 86* | 691 ± 174 | 1253 ± 324+ | 915 ± 148+ | 965 ± 252 | 643 ± 91 |
| NAt (μN/mm) | 71 ± 21 | 63 ± 11 | 422 ± 114* | 309 ± 105# | 1429 ± 639+ | 771 ± 269+ | 861 ± 330 | 1165 ± 549 |
| LHV/BW (mg/g) | 1.85 ± 0.05 | 1.95 ± 0.18 | 1.56 ± 0.04* | 1.63 ± 0.07# | 1.82 ± 0.07 | 1.98 ± 0.06 | 1.65 ± 0.09 | 1.81 ± 0.03 |
| AG/BW (mg/100 g) | 17.1 ± 0.7 | 16.1 ± 0.3 | 13.5 ± 0.3* | 13.8 ± 3# | 19.5 ± 0.7+ | 19.3 ± 0.4+ | 16.4 ± 3* | 15.7 ± 0.8# |
C7, 7-week controls; C9, 9-week controls; Post, Post-stress; Emax ACh, maximal relaxation to acetylcholine based on individual concentration-response curves; Emax SNP, maximal relaxation to sodium nitroprusside based on individual concentration-response curves; NAp, maximal phasic response to noradrenaline; NAt, maximal tonic response to noradrenaline; ND, normalized internal diameter of the femoral artery at 13.3 kPa; SNP, sodium nitroprusside; AG/BW, adrenal glands weight-to-body weight ratio; LHV/BW, left heart ventricle weight-to-body weight ratio. The results are mean ± SEM. ∗p < 0.05 vs. seven-week controls (C7) of the same phenotype, #p < 0.05 vs. stress of the same phenotype, +p < 0.05 vs. WKY of the same group.