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. 2018 Sep 4;8:13206. doi: 10.1038/s41598-018-31375-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Attenuation of CYZ-yfs and CYZ-hs variants in suckling mouse neurovirulence test compared to YF 17D vaccine benchmark control. 5-day old ICR suckling mice were inoculated IC with graded doses of viruses (the intended doses were −1 to 4 log₁₀ PFU for CYZs and wt Puerto Rico-2015 ZIKV, 1 to 3 log₁₀ PFU for ChimeriVax-JE, and −1 to 2 log₁₀ PFU for YF 17D). The Mock control group was inoculated with diluent, MEM supplemented with FBS. Mortalities are shown at doses determined by back-titration of the inoculates. LD₅₀ values of CYZs vs. YFV-17D were statistically different (P = 0.012; Mann Whitney test).