Table 2.

Association estimates for index SNPs associated at genome-wide significance with serum urate, and their corresponding association with gout.

SNP	Funct.	Closest Genes	Chr	Position	A1	A2	Freq.A1	Urate			Gout
								effect	SE	p-value	OR	95% CI	p-value
rs2231142	exonic	ABCG2	4	89052323	T	G	0.11	0.40	0.05	8.8E-14	1.54	1.34, 1.78	5.3E-09
rs13111638	intronic	SLC2A9	4	9996890	T	C	0.19	−0.31	0.04	2.0E-13	0.77	0.68, 0.86	2.9E-05

SNP indicates the SNP with the lowest p-value for urate; the index SNP at SLC2A9 for gout was rs59834205 (p-value 1.36E-07, LD with rs13111638: r² = 0.60, D′ = 0.79, using 1000 G phase 3); the index SNP at ABCG2 for gout was rs4148155 (p-value 4.54E-09; LD with rs2231142: r² = 0.99, D′ = 1, using 1000 G phase 3). Estimates for rs4148155 and rs59834205 are shown in Supplemental Table 2. Abbreviations: Funct., function; Chr, chromosome; A1, coded allele; A2, non-coded allele; Freq.A1, the frequency of the coded allele; effect, effect of A1; SE, standard error; OR, odds ratio; 95% CI, 95% confidence interval. Associations with urate were adjusted for age, sex, log(eGFR), BMI, significant principal components (p < 0.05), intake of diuretics and gout medication, while associations with gout were adjusted for age, sex, log(eGFR), BMI, and intake of diuretics. Associations were filtered for plausibility and quality.