Table 3.
Selected interactions between known urate-associated risk alleles in urate transporters and medications known to affect serum urate concentrations.
| SNP | Medication | With this medication | Without this medication | All (SNP × medication) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| effect | SE | p-value | n | effect | SE | p-value | n | effect | SE | p-value | n | ||
| SLC2A9 rs12498742 (G) | thiazide | −0.23 | 0.08 | 2.7E-03 | 1570 | −0.33 | 0.05 | 7.2E-13 | 3371 | 0.11 | 0.08 | 2.0E-01 | 4941 |
| loop diuretic | −0.37 | 0.07 | 1.0E-07 | 1900 | −0.25 | 0.05 | 1.5E-07 | 3041 | −0.08 | 0.08 | 2.9E-01 | 4941 | |
| ABCG2 rs2231142 (T) | thiazide | 0.37 | 0.10 | 3.1E-04 | 1570 | 0.43 | 0.06 | 3.0E-12 | 3371 | −0.06 | 0.11 | 6.0E-01 | 4941 |
| loop diuretic | 0.58 | 0.10 | 2.1E-09 | 1900 | 0.30 | 0.06 | 9.3E-07 | 3041 | 0.22 | 0.11 | 4.4E-02 | 4941 | |
| SLC17A1 rs1165151 (G) | thiazide | 0.14 | 0.06 | 2.5E-02 | 1570 | 0.03 | 0.04 | 4.4E-01 | 3371 | 0.10 | 0.07 | 1.5E-01 | 4941 |
| loop diuretic | −0.03 | 0.06 | 6.2E-01 | 1900 | 0.11 | 0.04 | 3.1E-03 | 3041 | −0.16 | 0.07 | 2.0E-02 | 4941 | |
| NRXN2/SLC22A12 rs478607 (A) | thiazide | −0.13 | 0.09 | 1.5E-01 | 1570 | −0.12 | 0.05 | 2.1E-02 | 3371 | −0.02 | 0.10 | 8.7E-01 | 4941 |
| loop diuretic | −0.29 | 0.08 | 4.5E-04 | 1900 | −0.01 | 0.05 | 7.9E-01 | 3041 | −0.27 | 0.09 | 3.6E-03 | 4941 | |
| SNP | Medication | Only this medication | No medication** | All (SNP × medication) | |||||||||
| effect | SE | p-value | n | effect | SE | p-value | n | effect | SE | p-value | n | ||
| SLC2A9 rs12498742 (G) | thiazide | −0.06 | 0.12 | 5.9E-01 | 604 | −0.29 | 0.06 | 3.9E-06 | 1503 | 0.23 | 0.12 | 6.3E-02 | 2107 |
| loop diuretic | −0.44 | 0.11 | 6.3E-05 | 589 | −0.29 | 0.06 | 3.9E-06 | 1503 | −0.17 | 0.12 | 1.6E-01 | 2092 | |
| ABCG2 rs2231142 (T) | thiazide | 0.35 | 0.16 | 3.3E-02 | 604 | 0.27 | 0.09 | 1.9E-03 | 1503 | 0.11 | 0.17 | 5.1E-01 | 2107 |
| loop diuretic | 0.66 | 0.17 | 1.6E-04 | 589 | 0.27 | 0.09 | 1.9E-03 | 1503 | 0.40 | 0.18 | 2.4E-02 | 2092 | |
| SLC17A1 rs1165151 (G) | thiazide | 0.24 | 0.10 | 2.1E-02 | 604 | 0.02 | 0.05 | 6.7E-01 | 1503 | 0.21 | 0.11 | 4.6E-02 | 2107 |
| loop diuretic | −0.02 | 0.10 | 8.8E-01 | 589 | 0.02 | 0.05 | 6.7E-01 | 1503 | −0.06 | 0.10 | 5.9E-01 | 2092 | |
| NRXN2/SLC22A12 rs478607 (A) | thiazide | 0.04 | 0.14 | 7.5E-01 | 604 | −0.03 | 0.07 | 6.9E-01 | 1503 | 0.08 | 0.14 | 5.8E-01 | 2107 |
| loop diuretic | −0.23 | 0.13 | 9.0E-02 | 589 | −0.03 | 0.07 | 6.9E-01 | 1503 | −0.21 | 0.14 | 1.4E-01 | 2092 | |
**No medication refers to not taking gout medications, diuretics and losartan. Associations were adjusted for age, sex, log(eGFR), BMI, and medications (gout medication, diuretics, losartan) other than the category being evaluated. The p-value for interaction adjusted for multiple testing was p < 2.5E-03. Rs12498742 (SLC2A9) is the reported index SNP from the GUGC Consortium and is in LD with rs13111638 (r2 = 0.74, D′ = 0.98).