Table 4.
Association between genome-wide significant SNPs and clinical characteristics of gout.
| Affected joints | Controls | Cases | % of female cases | SLC2A9 rs12498742 (G) | ABCG2 rs2231142 (T) | ||
|---|---|---|---|---|---|---|---|
| OR (95%CI) | p-value | OR (95%CI) | p-value | ||||
| shoulder | 2007 | 19 | 26.3% | 0.67 (0.25–1.47) | 3.6E-01 | 0.38 (0.06–1.27) | 1.9E-01 |
| elbow | 1988 | 38 | 10.5% | 0.36 (0.15–0.73) | 9.7E-03 | 0.92 (0.42–1.77) | 8.2E-01 |
| wrist | 1959 | 67 | 23.9% | 0.35 (0.18–0.60) | 4.7E-04 | 1.18 (0.70–1.89) | 5.1E-01 |
| finger | 1929 | 97 | 35.1% | 0.73 (0.49–1.04) | 9.7E-02 | 0.64 (0.37–1.04) | 9.3E-02 |
| knee | 1928 | 98 | 7.1% | 0.59 (0.39–0.87) | 1.0E-02 | 1.41 (0.94–2.07) | 8.7E-02 |
| ankle | 1903 | 123 | 14.6% | 0.67 (0.47–0.93) | 2.3E-02 | 1.47 (1.02–2.08) | 3.2E-02 |
| toe | 1504 | 522 | 20.5% | 0.92 (0.77–1.09) | 3.3E-01 | 1.15 (0.93–1.43) | 1.9E-01 |
| midfoot | 1816 | 210 | 21.4% | 0.61 (0.46–0.80) | 4.2E-04 | 1.31 (0.97–1.73) | 7.0E-02 |
Covariates included age, sex and log (eGFR). OR: Odds Ratio, 95% CI: 95% Confidence interval. For SLC2A9, rs12498742 is the previously reported index SNP from the GUGC Consortium; it is in LD with rs13111638 (r2 = 0.74, D′ = 0.98), the index SNP for SLC2A9 in the GCKD study. The p-value adjusted for multiple testing was p < 3.1E-03 (in bold).