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. 2018 Sep 4;4:32. doi: 10.1038/s41523-018-0084-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Construction of a sparse 12-channel image. a Hematoxylin and eosin-stained tissue are processed by a nuclear segmentation algorithm. Each nuclear feature is measured and represented on a single 2D array, where individual cells are represented as points. Arrays are stacked to form a 12D image. b Detailed view of 12 individual channels that would be stacked to form a 12-channel image