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Overview of DNA binding and oligomerization of SinR variants
| SinR variant | Binding of DNA motif (KDa [nM]) by fluorescence polarization |
Oligomerization status by SEC-MALS |
|---|---|---|
| Wild type | 179 ± 24 | Tetramer |
| K28T | No binding | Tetramer |
| S43A | 350 ± 81 | Tetramer |
| A85T | 852 ± 39 | Dissociating/unstable tetramer |
| W104L | 1,896 ± 298 | Dimer |
| W104R | 2,580 ± 545 | Dimer |
KD, dissociation constants.
