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. 2018 Sep 4;8:13195. doi: 10.1038/s41598-018-31436-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Significant brain activations during mental imagery and motor response tasks for one subject (P04). Whole brain activation maps are shown for tennis imagery, navigation imagery, squeeze imagery and motor response during five sessions: the first 15-min baseline task (Base1; no propofol infusion), the period before loss of responsiveness during propofol infusion (PreLOR), the period with loss of responsiveness (LOR), the period with recovery of responsiveness (ROR), and another 15-min baseline task (Base2; after recovery). Robust brain activations in SMA/PreM for tennis imagery and PreM for squeeze imagery during LOR were observed in this subject. All results were level-2 corrected at FPRs <5% of the individual level, with voxel-level p = 1.E-15 and a cluster size of 100 voxels (see Methods for more details).