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. 2018 Sep 4;8:13182. doi: 10.1038/s41598-018-31352-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Uptake of [¹⁴C]-metformin in HEK293-SLC22A1 cells expressing different alleles. Legend: Uptake of [³²S]-metformin by the SLC22A1 1022 C/T alleles. With 5 or 10 μM [¹⁴C]-metformin incubation, there was no significant difference in uptake between the two alleles. As the concentration increased, the uptake by SLC22A1 1022 T was less than that by the wild-type 1022 C allele. SLC22A1 1022 C is the wild-type allele, and 1022 T is the variant for this polymorphism.