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. 2018 Sep 4;9:3583. doi: 10.1038/s41467-018-05840-y

Table 1.

Summary of experimental data describing impact of WT versus mutants TRF1HP1α on telomere lengthening and TIF (via 47A or TRF2 depletion)

Baseline TRF1HP1α
WT V22M I165A W174A NS2A KRKAAA
Telomere lengthening +++ + + +++ ++ + +
TIF via 47A +++ + + +++ ++ ++ ++
TIF via si-TRF2 +++ + + +++ ++ + +

+++ (strong telomere lengthening, high number of TIF), ++ (intermediate phenotype), + (weak telomere lengthening, low number of TIF)