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. 2017 Jun 5;15(7):697–709. doi: 10.1038/cmi.2017.25

Figure 1.

Figure 1

The neutrophilic splenomegaly phenotype in lymphotoxin-deficient mice. (a) Spleens from SPF Ltbr +/+, littermate Ltbr +/− and Ltbr −/− mice were harvested and weighed. n=47, pooled from six repeats. (b) Trypan blue negative splenocytes counted with a hemocytometer from spleens in a. (c) Example flow plots showing the Gr1+CD11b+ population that has been gated on CD45+, CD3− and B220− populations from the spleen of Ltbr +/− and Ltbr −/− mouse, respectively. (d) SPF spleens were examined for percentage of neutrophils (CD45+, CD3−, B220−, Gr1+ and CD11b+) out of total splenocytes and (e) absolute neutrophil cell number. (a, b, d and e) Unpaired t-tests were performed. *P<0.05; **P<0.01; ****P<0.0001.