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. 2017 Jun 5;15(7):697–709. doi: 10.1038/cmi.2017.25

Figure 3.

Figure 3

The absence of lymphotoxin on RORγt expressing cells results in splenomegaly. (a) Conditional LTβR-deficient mice were generated by crossing Ltbr f/f mice with LysM Cre+ mice and Tie2 Cre+ mice (n=3–4, repeated two times). (b, c) Ltb f/f mice (n=3–13, repeated five times) were bred to Cd4 Cre+ and Cd19 Cre+mice to inactivate LT in T cells and B cells, respectively. Mice were killed, and the spleens were removed and weighed. Error bars represent the mean and s.e.m. One-way ANOVA was performed. **P<0.01; ***P<0.001.