Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Sep 4;3:34. doi: 10.1038/s41541-018-0057-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Vaccine induced antibody response profiles. a Heatmap shows changes in vaccine antigen-specific and control influenza hemagglutinin-specific antibody isotype titers after vaccination. Each row represents an individual. Each column represents an antibody isotype. The vaccine regimen is specified on the left with legend showing that red represents the top 5th percentile in the amount of change (large changes) and blue represents the 95th percentile in the amount of change (small changes). b Changes in ID93-specific antibody-dependent cellular cytotoxicity (ADCC) NK cell production of IFNγ, MIP1β, and CD107a, and antibody-dependent cellular phagocytosis (ADCP) are plotted. Each line represents each individual before (Day 0) and after (Day 84) vaccination and individuals are grouped by vaccine regimen. Statistical significance calculated by Wilcoxon matched pairs signed rank test is indicated (*p < 0.05, ***p < 0.001). c Spearman correlation coefficients between ID93 antibody-specific isotypes and ID93-specific antibody effector functions are depicted by bars with red denoting positive and blue denoting negative values. d Polyfunctionality as defined by total number of ID93-specific antibody effector functions (NK cell-mediated IFNγ, MIP1β, and CD107a, and antibody-dependent cellular phagocytosis) are graphed on a per individual basis. Each individual is represented by a dot, and individuals are grouped into vaccine regimens as noted (purple = ID93, green = ID93 + GLA-SE)