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. 2018 Sep 4;8:13204. doi: 10.1038/s41598-018-31604-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Domain structures of the postnatal OT and postnatal maturation of the anteromedial OT domain. (A) Reconstruction of the cap compartment, Islands of Calleja, and cortex-like domain of the OT at P3, P8, P15, and P56 in the left hemisphere (dorsal view). Orange, cap compartment; magenta, superficial Islands of Calleja; purple, deep Islands of Calleja; green, anteromedial cortex-like domain; yellow, lateral cortex-like domain; cyan, central cortex-like domain; blue, posterior cortex-like domain. (B) Molecular expression in the OT domains. The panels are coronal sections of the OT at postnatal periods indicated. Top row, NeuroTrace staining; second row from top, immunostaining for DARPP-32; middle row, merged view of NeuroTrace (green) and DARPP-32 (red). Second row from bottom, in situ hybridisation for dopamine receptor type 1 (D1) mRNA; bottom row, dopamine receptor type 2 (D2) mRNA. Scale bars: 200 μm. A, anterior; P, posterior; L, lateral; M, medial; D, dorsal; V, ventral.