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. 2018 Aug 29;12:285. doi: 10.3389/fncel.2018.00285

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Copyright © 2018 Wang, Guan, Zhao, Zhu, Song and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, *p < 0.05, **p < 0.01, ***p < 0.001 relative to control; n = 5.