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. 2018 Sep 3;1:131. doi: 10.1038/s42003-018-0137-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — ImmunoFISH for bone marrow stromal cell markers in case 1. PDGFRβ, blue; X, magenta; Y, green; DAPI, gray. a PDGFRβ-immunoFISH analysis in the tumor specimen. Recipient-derived PDGFRβ(+) SCSSNs and donor-derived PDGFRβ(−) SCSSNs are observed. Recipient-derived PDGFRβ(+) SCSSNs are indicated by white arrows. Scale bar: 100 μm. b Proportions of donor cells in a region comprising 50 continuous HPFs. Each analysis was carried out in six regions of the tumor area. The means (SD, total number of PDGFRβ(+) SCSSNs, number of sections) were as follows: 0.7% (0.8%, 578, 2) in case 1, 2.4% (1.9%, 258, 3) in case 2, and 1.8% (2.1%, 182, 2) in case 3. (PDGFRβ-immunoFISH images for cases 2 and 3 are shown in Supplementary Figs. 2 and 3). c PDGFRβ-immunoFISH analysis in the bone marrow specimen. Most PDGFRβ(+) cells are recipient-derived (white arrow). Cells marked weakly positive for PDGFRβ (weak+) are suspected to be donor-derived (yellow arrow). Scale bar: 100 μm