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. 2018 Jul 18;19(9):e45775. doi: 10.15252/embr.201845775

Figure 2. Identification and bioinformatics analysis of UC1 domain of cavin1.

Figure 2

  1. A cladogram was constructed using the sequences shown in Fig EV2, and red numbers at nodes show branch support values. Marked in blue are species in the clade Sarcopterygii; pink (cavin1b) and green (cavin1a) colour represent species in the clade Actinopterygii. The number of UC1 domain repeats in cavin1 is shown in black circles with exceptions marked in squares.
  2. Amino acid sequence alignment of mouse cavin1 and zebrafish cavin1b HR2 domains highlighting conserved inserts in the HR2 domain.
  3. The cavin1 HR2 insert is composed of an eleven residue (undecad) repeat of the sequence [ML]EKT[KR]x[KR]T[KR]EN. Mouse (and human) cavin1 contains two repeats, while zebrafish cavin1b contains five.
  4. Model of human and zebrafish cavin1 undecad repeats based on the undecad repeats of the trimeric autotransporter adhesin EIBD (PDB 2XQH).