Table 1.
Replicating variants associated with DDH
| SNP ID (chromosome: position) | Effect allele/other allele | Effect allele frequency (discovery stage) | Discovery odds ratio (95% CI) | Discovery P-value | Replication odds ratio (95% CI) | Replication P-value | Meta-analysis odds ratio (95% CI) | Meta-analysis P-value |
|---|---|---|---|---|---|---|---|---|
| rs143384 (20:34025756) | A/G | 0.60 | 1.57 (1.40–1.77) | 1.72 × 10−14 | 1.37 (1.24–1.51) | 1.33 × 10−10 | 1.44 (1.34–1.56) | 3.55 × 10−22 |
| rs4740554 (9:13688437) | C/A | 0.10 | 1.44 (1.22–1.71) | 4.09 × 10−05 | 1.20 (1.03–1.39) | 0.01 | 1.30 (1.16–1.45) | 4.44 × 10−6 |
| rs4919218 (10:100111392) | C/T | 0.69 | 1.27 (1.13–1.43) | 6.48 × 10−05 | 1.14 (1.03–1.25) | 0.0089 | 1.19 (1.10–1.28) | 4.38 × 10−6 |