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. 2018 May 3;1:36. doi: 10.1038/s42003-018-0042-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Effect of genome-wide significant SNPs for risk-taking on BMI. Each data point represents one of the 26 risk-associated SNPs. The SNP-specific MR estimate for the association of risk-taking with BMI (x axis) is plotted against the SE (y axis). The summary estimate is marked by the solid black line. The grey-dotted lines, originating from the summary estimate, represent 95% confidence limits. The red-dotted line indicates the null