Table 3.
Associations between the four risk-taking loci that were genome-wide significant signals for BMI and diet-related traits
| Variant | Implicated gene | BMI | TV snacking | Home-cooked meals | Skipping breakfast | Energy (kcal/day) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta (SE) | P value | Beta (SE) | P value | Beta (SE) | P value | Beta (SE) | P value | Beta (SE) | P value | ||
| rs891124 | CALB2 | 0.01 (0.002) | 3.5 × 10−10 | 0.12 (0.05) | 0.02* | 0.04 (0.03) | 0.21 | 0.01 (0.03) | 0.86 | 3.86 (11.0) | 0.73 |
| rs35914833 | PRIMA1 | 0.02 (0.002) | 5.3 × 10−14 | −0.05 (0.05) | 0.34 | −0.03 (0.03) | 0.33 | −0.04 (0.03) | 0.20 | 30.3 (11.0) | 0.01* |
| rs6762267 | CADM2 | 0.02 (0.002) | 1.7 × 10−15 | 0.09 (0.05) | 0.07 | 0.02 (0.03) | 0.45 | −0.03 (0.03) | 0.36 | 12.3 (10.2) | 0.23 |
| rs7817124 | ZBTB10 | −0.01 (0.002) | 1.8 × 10−9 | 0.09 (0.06) | 0.10 | −0.03 (0.03) | 0.36 | 0.08 (0.03) | 0.02* | 12.4 (11.5) | 0.28 |
SNPs were aligned to the risk-taking propensity-increasing allele. Effect estimates (beta and SE) were derived from linear or logistic regressions of the variant to the named trait, adjusted for age and sex. BMI was a continuous outcome standardised within the BMI meta-analysis. TV snacking was coded: 0 never/rarely; 1 occasionally/ usually/ always; skipping breakfast was coded: 0 skips breakfast <2 times a week; 1 skips breakfast ≥2 times a week; home-cooked food was coded: 0:>5 meals a week home-cooked, 1:<5 meals a week are home-cooked
*Nominally significant (P < 0.05)