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. 2018 May 3;1:45. doi: 10.1038/s42003-018-0046-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Impaired P. falciparum invasion into Lan-negative erythrocytes is independent of Lan null genotype, and is strain-transcendent. a Comparison of invasion by P. falciparum strain 3D7 into erythrocytes from five unrelated Lan null individuals (#1–5; see Table 1 for details of samples) and seven Lan-positive control individuals (#6–10 and 12–13), which serve as biological replicates. Samples 1–9 were previously cryopreserved and thawed, and samples 10,12, and13 were fresh. b–f Invasion by five additional P. falciparum strains (W2mef, D10, HB3, 7G8, and 3D7ΔRh2B, respectively). Invasion was measured by SYBR green I staining and flow cytometry. Values are expressed as mean parasitemia ±SD, n = 2. ****p ≤ 0.0001, ***p = 0.0002, two-tailed t-tests. g Invasion by P. falciparum strain 3D7 or four clinical isolates from malaria patients in Senegal (82.09. Th032.09, Th79.09, and Th026.09) into Lan null or Lan-positive erythrocytes. Invasion was measured by SYBR green I staining and flow cytometry. Values are expressed as mean parasitemia ±SD, n = 2