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. 2018 Jun 18;1:72. doi: 10.1038/s42003-018-0074-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Comparison of the vascular morphometric parameters between implant types characterizing the features of the vessel network: branching number; vascular volume, and vessel length from day 7 to day 15 post-surgery. In all: Black = TiMA day 7; Gold = TiMA day 15; Green = TiNT day 7; Azure = TiNT day 15. Branching number of the network in a TiMA and b TiNT groups. Error bar = median ± IQR. n = 8 animals/group/time point. Mann–Whitney test was used to assess the statistical significance of the two medians ***P-value < 0.001. c comparison of the vessel volume in both TiMA and TiNT implant groups in day 7 and 15 post-surgery; error bar = mean ± SEM. d comparison of the vessel length in both TiMA and TiNT implant groups in day 7 and 15 post-surgery; error bar = median ± IQR. In c, d, n = 8 animals/group/time point. Kruskal–Wallis test was performed followed by a Dunn’s multiple comparison test. NS not significant, **P-value < 0.01, ***P-value < 0.001