Figure 1.

Seizure latencies and pre-seizures electroencephalography (EEG) signals. (A) Non-convulsive seizures (NCS) and convulsive seizures (CS) latencies measured from mice that exhibited both types of seizures following different middle cerebral artery occlusion (MCAO) protocols via intraluminal suture insertion. *, NCS vs. CS. (B,C) Representative traces collected from two mice; ipsilateral hippocampal signals sampled during baseline monitoring (before MCAO) and immediately before the onset of the first NCS or CS (pre-seizure). (D,E) Data collected from two groups of mice with NCS or CS as the first detected seizure within 30 min following MCAO. Seizure latencies were determined from termination of surgery to the onset of the first seizure. Pre-seizure signal powers were normalized as percentiles of baseline measures. *, pre-NCS vs. pre-CS signals. Here and in following figures, ipsilateral and contralateral are in reference to unilateral MCAO; data are presented as mean ± SEM except where specified; *indicates significance at p < 0.05.