Fig. 3.

αS–lipid interaction is favored by increased membrane plasticity. [¹⁵N]-αS (50 µM) NMR attenuation profiles in the presence of 25 µM NDs with indicated lipid composition (molar ratio 2:1, αS-to-NDs) for bilayers that are in a more fluid a or gel phase b at 10 °C. It is noteworthy that all NMR data are recorded at 10 °C and pH 7.4 with the exception of one of the 100% DMPG samples (b, red bars) that was recorded at 37 °C and pH 5.3. c Corresponding ThT aggregation assays (50 µM αS, 25 µM NDs) for selected conditions (for better visibility only the mean values of triplicate measurements are shown, colors correspond to respective attenuation profiles in a, b)