Table V.

Next-generation sequencing data for protein tyrosine phosphatase non-receptor 11 (PTPN11), phosphatase and tensin homolog (PTEN) and tumor protein 53 (TP53) variants in high-grade glioma (HGG) tumors tend to be race-specific. Each variant is characterized by specific amino acid substitution at a given protein position, the specific DNA exon region, its pathogenicity, and the actual number of patients represented in each cohort (n). Standard one letter codes are used to indicate mutation-induced changes in amino acids.

Gene/variant	Exon	Function	AA (n)	CC (n)	p-Value
PTPN11
Total assayed			18	57	0.011‡
G503V	13	PP	2	0
T507A	13	PP	1	0
PTEN
Total assayed			18	55	0.005‡
Q17X	1	P	0	1
T26fs	1	P	0	2
G129V	5	PP	0	1
Q87X	5	P	0	1
L193fs	6	P	0	1
Q171X	6	P	0	1
R173H	6	P	0	1
Y176fs	6	P	0	1
Y180X	6	P	0	1
I253fs	7	P	0	2
P246L	7	P	0	1
S226fs	7	P	0	1
R335X	8	P	0	1
V317fs	8	P	0	1
V315X	8	P	0	2
TP53
Total assayed			18	58	0.024‡
N29fs	3	P	0	1
H115fs	4	P	0	1
L130V	5	PP	0	1
R175H	5	P	0	2
R181H	5	PP	0	1
V143A	5	PP	0	1
H193P	6	PP	0	1
I195T	6	PP	0	1
Y205fs	6	P	0	1
Y220C	6	P	0	1
G244D	7	PP	0	1
R248Q	7	P	0	2
Y234C	7	PP	0	1
C275S	8	PP	1	0
F270L	8	PP	1	0
G266E	8	PP	0	1
P278S	8	PP	0	1
P301fs	8	P	0	2
R267W	8	PP	0	1
R273C	8	5	0	5
R273H	8	P	1	1
R306X	8	P	0	1
R337C	10	P	0	1
R342X	10	P	0	1

AA, African Americans; CC, Caucasians; Fs, frameshift; P, pathogenic; PP, presumed pathogenic; X, stop codon.

^‡Chi-square test.