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Conservation scores of NRG1 variants
| Variant | GERP | PhyloP placental | PhyloP vertebrate | SiPhy |
| c.397G > C (p.V133 L) | 4.26 (deleterious) |
1.55 (non-deleterious) |
1.799 (deleterious) |
10.121 (non-deleterious) |
| rs7834206 | 0 | 0 | 0 | 0 |
| rs3735774 | 5.15 | 2.894 | 0.784 | 9.461 |
| rs75155858 | 4.71 | 1.321 | 3.472 | 10.265 |
| Conservation scores interpretation: | ||||
| Method | Deleterious cutoff | |||
| GERP | > 2 | |||
| PhyloP | > 1.6 | |||
| SiPhy | > 12.17 | |||
