Table 1.

Hydration protocol used for cases enrolled in the study during platinum based drugs (PBD)

• Before PBD:

i. 1000 mL Sodium Chloride 0.9%

ii. 500 ml sodium chloride with 20mmolKCL

iii. 500 ml sodium chloride with 10 mmol MgSO4

• During administration of PBD: PBD is given in 1000 mL Sodium Chloride 0.9% infused over 2 h

• After PBD: 1000 mL Sodium Chloride 0.9% with 20 mmol KCL and 10 mmol MgSO4 IV

• Monitoring during chemotherapy:

i. Monitor urine output at regular intervals throughout chemotherapy

ii. At the end of IV fluids, weigh the patient and review fluid input and output

iii. Re-weigh the patient – if they have gained > 2 kg, they should be prescribed furosemide 20 mg orally and urine output monitored for a further 30 min.

• Pre-discharge:

i. Ensure the patient is able to maintain good oral fluid intake

ii. Patient should be advised to drink a lot of fluids

iii. Advise patient to contact the hospital if unable to drink due to vomiting