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. 2018 Sep 4;20:105. doi: 10.1186/s13058-018-1020-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) analysis of claudin-low triple-negative breast cancer (TNBC) patients. The claudin-low subgroup analyzed in the METABRIC study represented a cluster of 125 patients characterized by 112 TNBC and 13 ER⁻/PR⁻/HER2⁺ specimens, and the average of age at diagnosis was 56.9 years. NOTCH3 alterations characterized by messenger RNA upregulation and/or copy number variations were detected in 8 of 117 cases (6 TNBC and 2 ER⁻/PR⁻/HER2⁺). Cases of death involved 6 patients with aberrant NOTCH3 expression and 46 patients without NOTCH3 alterations. Survival analysis showed that NOTCH3 expression was significantly associated with decreased overall survival (p = 0.0145)