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. 2018 Sep 4;19:472. doi: 10.1186/s13063-018-2868-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Study procedures and assessments. ICU intensive care unit, SOFA sequential organ failure assessment; 1 maximum of 1 h after randomization; 2 22–26 h after randomization; 3 ≤6 h before and maximum of 3 h after randomization; 4 Sepsis criteria, routine biochemistry, microbiological results, medication, anti-infectious measures, and SOFA score; 5 As soon as all baseline microbiological results are available