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. 2018 Aug 29;9:999. doi: 10.3389/fphar.2018.00999

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Copyright © 2018 Yang, Yan, Wang, Tian, Lu, Wu, Xu, Wu, Liu, Mao, Xu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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T11 decreased the activation of NF-κB signaling pathway in LPS-stimulated RAW 264.7 cells. (A) The proteins levels of TAK1, p-TAK1 and TAB1 were detected by western blot. (B) TAK1 expression. (C) p-TAK1 expression. (D) TAB1 expression. (E) The proteins levels of IκBα, p-IκBα and NF-κB (p65) were detected by western blot. (F) IκBα expression. (G) p-IκBα expression. (H) NF-κB (p65) expression. The data reveal as the mean ± SEM (n = 3 in each group). Group comparisons were performed by one-way analysis of variance (ANOVA) followed by post hoc Tukey’s test or Student’s t-test when appropriate. P < 0.05 was considered as statistical significance.