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Knockdown of CLIC3 expression inhibits human osteoblast differentiation. Transduction of hMSCs with 2 shRNAs against CLIC3 (shaded bars) reduces (A) mRNA expression of CLIC3 as determined by quantitative PCR (day 4), (B) total protein (day 6), (C) ALP activity (day 6), and (D) mineralization (week 3) compared to scrambled control (white bar). Graphs display combined results from all experiments. (A) n = 4–5; (B) n = 7; (C) n = 7; (D) n = 6. **p < 0.01, ***p < 0.001.
