Table 4.
Summary of Top of Canonical Pathways and GO Terms
| Canonical pathway a | Biological process b | Molecular function b | Cellular component b |
|---|---|---|---|
| PRPP biosynthesis | Export from nucleus | RNA binding | Adherens cell junction |
| Gap junction signaling | RNA localization | Cadherin binding | Cytosol |
| Paxillin signaling | Transport | Cell adhesion: protein and molecule binding | Nuclear periphery/pore |
| Integrin signaling | Adhesion | ||
| Endocytosis/exocytosis |
Top canonical pathways determined by Ingenuity pathway analysis from the 52 proteins found to pull down with Clic3‐His. GO term clusters that have been identified by DAVID bioinformatics resources for the same proteins. The GO terms within the clusters had a significance of Benjamini corrected p value <0.05. The headers “biological process,” “molecular function,” and “cellular components” stand for the GO category to which the GO term is annotated.
a
Determined by Ingenuity pathway analysis (http://www.ingenuity.com/).
b
Determined by DAVID Functional Annotation Analysis (http://david.ncifcrf.gov).