Table 1.
Genes differentially regulated >50% three days post-TIC injury.
| Transcript ID | Gene assignment | Gene symbol | TIC/naïve ratio | p Values | q Values |
|---|---|---|---|---|---|
| Upregulated | |||||
| 17407412 | Small proline-rich protein 1A | Sprr1a | 174.86 | 4.81E-06 | 3.23E-04 |
| 17360942 | Galanin | Gal | 25.96 | 1.52E-05 | 5.07E-04 |
| 17231033 | Activating transcription factor 3 | Atf3 | 7.84 | 6.45E-06 | 3.23E-04 |
| 17244601 | Neurotensin | Nts | 7.32 | 2.56E-04 | 3.20E-03 |
| 17485098 | Mucin 5, subtype B, tracheobronchial | Muc5b | 6.95 | 1.59E-01 | 3.00E-01 |
| 17343170 | Trefoil factor 2 (spasmolytic protein 1) | Tff2 | 6.75 | 1.52E-01 | 2.96E-01 |
| 17253215 | Solute carrier family 6 (neurotransmitter transporter) | Slc6a4 | 5.25 | 1.44E-03 | 8.48E-03 |
| 17458514 | Neuropeptide Y | Npy | 4.97 | 5.66E-04 | 5.65E-03 |
| 17344943 | Cysteine-rich secretory protein 3 | Crisp3 | 4.55 | 2.05E-01 | 3.22E-01 |
| 17483925 | Deleted in malignant brain tumors 1 | Dmbt1 | 4.32 | 3.51E-01 | 3.78E-01 |
| 17318815 | Apolipoprotein L 11b | Apol11b | 4.17 | 5.74E-02 | 1.64E-01 |
| 17495622 | Glycoprotein 2 (zymogen granule membrane) | Gp2 | 4.09 | 1.93E-01 | 3.18E-01 |
| 17268243 | Beta-1,4-N-acetyl-galactosaminyl transferase 2 | B4galnt2 | 4.08 | 2.31E-01 | 3.36E-01 |
| 17481378 | Cholecystokinin B receptor | Cckbr | 4.00 | 1.03E-04 | 1.71E-03 |
| 17275015 | Anterior gradient 2 (Xenopus laevis) | Agr2 | 3.98 | 2.41E-01 | 3.45E-01 |
| 17467973 | Regenerating islet-derived 3 gamma | Reg3g | 3.96 | 1.48E-01 | 2.96E-01 |
| 17354074 | G protein-coupled receptor 151 | Gpr151 | 3.81 | 4.54E-04 | 5.04E-03 |
| 17517097 | RIKEN cDNA 1600029D21 gene | 1600029D21Rik | 3.65 | 9.46E-02 | 2.36E-01 |
| 17225224 | Endothelin converting enzyme-like 1 | Ecel1 | 3.59 | 1.37E-03 | 8.48E-03 |
| 17251091 | Myosin, heavy polypeptide 4, skeletal muscle | Myh4 | 3.58 | 1.01E-01 | 2.47E-01 |
| 17522555 | Lactotransferrin | Ltf | 3.50 | 3.18E-01 | 3.70E-01 |
| 17334172 | Demilune cell and parotid protein 2 | Dcpp2 | 3.49 | 2.06E-01 | 3.22E-01 |
| 17266851 | Schlafen 9 | Slfn9 | 3.33 | 1.55E-02 | 5.52E-02 |
| 17358749 | Lipase, family member N | Lipn | 3.32 | 1.34E-03 | 8.48E-03 |
| 17497525 | A disintegrin and metallopeptidase domain 8 | Adam8 | 3.29 | 6.22E-04 | 5.65E-03 |
| 17459309 | Immunoglobulin kappa variable 14-126 | Igkv14-126 | 3.17 | 1.09E-01 | 2.60E-01 |
| 17216960 | Polymeric immunoglobulin receptor | Pigr | 3.13 | 1.73E-01 | 3.09E-01 |
| 17358724 | Lipase, gastric | Lipf | 3.10 | 3.51E-01 | 3.78E-01 |
| 17524311 | Mucin 16 | Muc16 | 2.91 | 1.62E-01 | 3.01E-01 |
| 17245231 | Lysozyme 1 | Lyz1 | 2.83 | 4.82E-01 | 4.92E-01 |
| 17438684 | Odontogenic, ameloblast asssociated | Odam | 2.83 | 2.32E-01 | 3.36E-01 |
| 17496211 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | Atp2a1 | 2.77 | 2.88E-01 | 3.54E-01 |
| 17378149 | BPI fold containing family B, member 1 | Bpifb1 | 2.74 | 3.50E-01 | 3.78E-01 |
| 17463338 | Fibroblast growth factor 23 | Fgf23 | 2.68 | 6.46E-03 | 2.58E-02 |
| 17392255 | Fibronectin leucine rich transmembrane protein 3 | Flrt3 | 2.66 | 2.22E-04 | 3.17E-03 |
| 17318083 | Lymphocyte antigen 6 complex, locus A | Ly6a | 2.56 | 1.91E-02 | 6.24E-02 |
| 17438963 | Pro-platelet basic protein | Ppbp | 2.56 | 3.88E-01 | 4.04E-01 |
| 17500195 | Steroidogenic acute regulatory protein | Star | 2.55 | 1.28E-03 | 8.48E-03 |
| 17270162 | Solute carrier family 4 (anion exchanger), member 1 | Slc4a1 | 2.49 | 3.69E-01 | 3.93E-01 |
| 17531701 | Predicted gene, 20317 | Gm20317 | 2.48 | 1.79E-01 | 3.14E-01 |
| 17296344 | Follistatin | Fst | 2.46 | 3.95E-03 | 1.88E-02 |
| 17314373 | Mucin 19 | Muc19 | 2.42 | 2.01E-01 | 3.22E-01 |
| 17254295 | Extracellular proteinase inhibitor | Expi | 2.41 | 4.37E-01 | 4.51E-01 |
| 17284507 | Immunoglobulin heavy chain (gamma polypeptide) | Ighg | 2.40 | 1.66E-01 | 3.01E-01 |
| 17474621 | Creatine kinase, muscle | Ckm | 2.40 | 2.94E-01 | 3.54E-01 |
| 17273304 | Carbonyl reductase 2 | Cbr2 | 2.36 | 1.23E-01 | 2.73E-01 |
| 17337458 | Tripartite motif-containing 10 | Trim10 | 2.35 | 1.53E-01 | 2.96E-01 |
| 17467316 | Growth arrest and DNA-damage-inducible 45 alpha | Gadd45a | 2.34 | 9.45E-04 | 7.47E-03 |
| 17509565 | Annexin A10 | Anxa10 | 2.33 | 1.01E-02 | 3.88E-02 |
| 17547647 | Predicted gene 9241 | Gm9241 | 2.30 | 1.93E-02 | 6.24E-02 |
| Downregulated | |||||
| 17491349 | MAS-related GPR, member B5 | Mrgprb5 | 0.45 | 3.89E-02 | 3.89E-02 |
| 17479944 | Olfactory receptor 295 | Olfr295 | 0.49 | 1.74E-02 | 3.48E-02 |
Note: The top 50 upregulated and two downregulated genes at the three-day time point after TIC injury are shown compared to the naïve control group with their p values and a false discovery rate of 5% (q value; n = 6 per group). Bold font indicates genes uniquely expressed on Day 3 but not on Day 21.