Table 2.
Genes differentially regulated >50% 21 days post-TIC injury.
| Transcript ID | Gene assignment | Gene symbol | TIC/naïve ratio | p Values | q Values |
|---|---|---|---|---|---|
| Upregulated | |||||
| 17407412 | Small proline-rich protein 1A | Sprr1a | 15.44 | 4.46E-04 | 1.12E-02 |
| 17244601 | Neurotensin | Nts | 4.69 | 1.32E-03 | 1.89E-02 |
| 17231033 | Activating transcription factor 3 | Atf3 | 2.74 | 9.49E-04 | 1.58E-02 |
| 17481378 | Cholecystokinin B receptor | Cckbr | 2.72 | 9.17E-04 | 1.58E-02 |
| 17360942 | Galanin | Gal | 2.40 | 3.76E-02 | 7.10E-02 |
| 17219639 | Olfactory receptor 418, pseudogene 1 | Olfr418-ps1 | 2.25 | 2.05E-03 | 2.28E-02 |
| 17362953 | Membrane-spanning 4-domains, subfamily A, member 7 | Ms4a7 | 2.16 | 2.78E-03 | 2.53E-02 |
| 17273694 | Pro-opiomelanocortin-alpha | Pomc | 2.06 | 4.60E-01 | 4.70E-01 |
| 17225224 | Endothelin converting enzyme-like 1 | Ecel1 | 2.00 | 3.19E-02 | 6.77E-02 |
| 17463619 | Proline rich protein 2 | Prp2 | 1.86 | 1.38E-01 | 1.75E-01 |
| 17266851 | Schlafen 9 | Slfn9 | 1.83 | 1.62E-01 | 1.86E-01 |
| 17500195 | Steroidogenic acute regulatory protein | Star | 1.83 | 1.43E-02 | 4.76E-02 |
| 17421521 | Predicted gene 13154 | Gm13154 | 1.79 | 1.66E-04 | 1.08E-02 |
| 17449585 | Betacellulin, epidermal growth factor family member | Btc | 1.77 | 2.87E-04 | 1.08E-02 |
| 17318083 | Lymphocyte antigen 6 complex, locus A | Ly6a | 1.76 | 1.16E-01 | 1.52E-01 |
| 17264835 | CD68 antigen | Cd68 | 1.76 | 2.87E-02 | 6.74E-02 |
| 17366355 | Component of Sp100-rs | Csprs | 1.72 | 3.62E-02 | 7.05E-02 |
| 17497637 | Olfactory receptor 524 | Olfr524 | 1.71 | 2.10E-02 | 5.82E-02 |
| 17285677 | Histone cluster 1, H2ao | Hist1h2ao | 1.71 | 6.48E-03 | 3.79E-02 |
| 17532710 | Predicted gene 14347 | Gm14347 | 1.67 | 7.65E-03 | 3.82E-02 |
| 17491349 | MAS-related GPR, member B5 | Mrgprb5 | 1.67 | 1.51E-01 | 1.80E-01 |
| 17458960 | Vomeronasal 1 receptor 20 | Vmn1r20 | 1.66 | 7.18E-02 | 1.04E-01 |
| 17494710 | Olfactory receptor 707 | Olfr707 | 1.65 | 2.78E-02 | 6.74E-02 |
| 17458439 | Glycoprotein (transmembrane) nmb | Gpnmb | 1.65 | 2.44E-02 | 6.41E-02 |
| 17230078 | Myeloid cell nuclear differentiation antigen | Mnda | 1.65 | 1.71E-01 | 1.86E-01 |
| 17525471 | Predicted gene 3434 | Gm3434 | 1.63 | 7.33E-03 | 3.82E-02 |
| 17548752 | Transmembrane protein 202 | Tmem202 | 1.61 | 4.93E-02 | 8.22E-02 |
| 17286434 | Serine (or cysteine) peptidase inhibitor, clade B, member 9g | Serpinb9g | 1.61 | 2.57E-02 | 6.43E-02 |
| 17387662 | Olfactory receptor 1054 | Olfr1054 | 1.60 | 6.03E-02 | 9.42E-02 |
| 17358749 | Lipase, family member N | Lipn | 1.60 | 9.59E-02 | 1.31E-01 |
| 17358832 | Interferon-induced protein with tetratricopeptide repeats 1 | Ifit1 | 1.60 | 3.32E-02 | 6.77E-02 |
| 17242322 | Predicted gene 9507 | Gm9507 | 1.59 | 6.19E-03 | 3.79E-02 |
| 17544295 | Serine-rich, secreted, X-linked | Srsx | 1.59 | 1.03E-01 | 1.37E-01 |
| 17483192 | Seizure related 6 homolog like 2 | Sez6l2 | 1.59 | 4.81E-01 | 4.84E-01 |
| 17331258 | Olfactory receptor 197 | Olfr197 | 1.59 | 1.78E-03 | 2.22E-02 |
| 17546316 | Eukaryotic translation initiation factor 2, subunit 3 | Eif2s3y | 1.58 | 1.55E-01 | 1.82E-01 |
| 17285746 | Histone cluster 1, H2bn | Hist1h2bn | 1.58 | 6.99E-02 | 1.04E-01 |
| 17545543 | Predicted gene 16390 | Gm16390 | 1.57 | 3.01E-02 | 6.74E-02 |
| 17429512 | MicroRNA 30c-1 | Mir30c-1 | 1.57 | 2.53E-01 | 2.61E-01 |
| 17489547 | Predicted gene 6725 | Gm6725 | 1.57 | 2.01E-02 | 5.81E-02 |
| 17244563 | Citrate synthase like | Csl | 1.56 | 1.57E-02 | 4.91E-02 |
| 17263765 | Solute carrier family 47, member 1 | Slc47a1 | 1.56 | 2.14E-01 | 2.27E-01 |
| 17212364 | RIKEN cDNA 1500015O10 gene | 1500015O10Rik | 1.55 | 1.38E-01 | 1.75E-01 |
| 17217048 | RIKEN cDNA 5430435G22 gene | 5430435G22Rik | 1.55 | 6.03E-03 | 3.79E-02 |
| 17533462 | Predicted gene 5382 | Gm5382 | 1.55 | 1.63E-01 | 1.86E-01 |
| 17467108 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | Lsm5 | 1.54 | 2.46E-03 | 2.46E-02 |
| 17477055 | Expressed sequence EU599041 | EU599041 | 1.53 | 7.16E-02 | 1.04E-01 |
| 17407400 | Small proline-rich protein 1B | Sprr1b | 1.52 | 1.48E-02 | 4.77E-02 |
| 17448676 | Predicted gene 5868 | Gm5868 | 1.52 | 4.25E-02 | 7.58E-02 |
| 17500702 | A disintegrin and metallopeptidase domain 25 (testase 2) | Adam25 | 1.52 | 9.92E-03 | 4.06E-02 |
| Downregulated | |||||
| 17483925 | Deleted in malignant brain tumors 1 | Dmbt1 | 0.11 | 1.77E-01 | 4.03E-01 |
| 17245231 | Lysozyme 1 | Lyz1 | 0.12 | 1.68E-01 | 4.03E-01 |
| 17358724 | Lipase, gastric | Lipf | 0.14 | 1.27E-01 | 4.03E-01 |
| 17378149 | BPI fold containing family B, member 1 | Bpifb1 | 0.16 | 1.07E-01 | 4.03E-01 |
| 17522555 | Lactotransferrin | Ltf | 0.18 | 1.83E-01 | 4.03E-01 |
| 17254295 | Extracellular proteinase inhibitor | Expi | 0.18 | 1.51E-01 | 4.03E-01 |
| 17485098 | Mucin 5, subtype B, tracheobronchial | Muc5b | 0.20 | 2.30E-01 | 4.03E-01 |
| 17305520 | Eosinophil-associated, ribonuclease A family, member 1 | Ear1 | 0.20 | 2.71E-01 | 4.03E-01 |
| 17343170 | Trefoil factor 2 (spasmolytic protein 1) | Tff2 | 0.24 | 2.66E-01 | 4.03E-01 |
| 17502789 | Glycophorin A | Gypa | 0.27 | 2.85E-01 | 4.03E-01 |
| 17408897 | Chitinase 3-like 3 | Chi3l3 | 0.30 | 2.89E-01 | 4.03E-01 |
| 17268243 | Beta-1,4-N-acetyl-galactosaminyl transferase 2 | B4galnt2 | 0.32 | 3.19E-01 | 4.03E-01 |
| 17326075 | Resistin like gamma | Retnlg | 0.33 | 2.50E-01 | 4.03E-01 |
| 17312219 | Lymphocyte antigen 6 complex, locus G | Ly6g | 0.34 | 3.49E-01 | 4.03E-01 |
| 17399823 | S100 calcium binding protein A8 (calgranulin A) | S100a8 | 0.34 | 3.40E-01 | 4.03E-01 |
| 17407363 | S100 calcium binding protein A9 (calgranulin B) | S100a9 | 0.35 | 2.65E-01 | 4.03E-01 |
| 17495622 | Glycoprotein 2 (zymogen granule membrane) | Gp2 | 0.35 | 3.23E-01 | 4.03E-01 |
| 17270162 | Solute carrier family 4 (anion exchanger),member 1 | Slc4a1 | 0.35 | 3.10E-01 | 4.03E-01 |
| 17522369 | Neutrophilic granule protein | Ngp | 0.36 | 3.51E-01 | 4.03E-01 |
| 17337706 | Rhesus blood group-associated A glycoprotein | Rhag | 0.36 | 1.71E-01 | 4.03E-01 |
| 17496211 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | Atp2a1 | 0.37 | 2.94E-01 | 4.03E-01 |
| 17275015 | Anterior gradient 2 (Xenopus laevis) | Agr2 | 0.37 | 3.89E-01 | 4.11E-01 |
| 17251046 | Myosin, heavy polypeptide 1, skeletal muscle, adult | Myh1 | 0.38 | 3.71E-01 | 4.08E-01 |
| 17350267 | Myotilin | Myot | 0.38 | 2.29E-01 | 4.03E-01 |
| 17284354 | Immunoglobulin heavy chain (J558 family) | Igh-VJ558 | 0.39 | 2.14E-01 | 4.03E-01 |
| 17371296 | Xin actin-binding repeat containing 2 | Xirp2 | 0.39 | 1.64E-01 | 4.03E-01 |
| 17485246 | Troponin T3, skeletal, fast | Tnnt3 | 0.40 | 2.88E-01 | 4.03E-01 |
| 17303874 | Myozenin 1 | Myoz1 | 0.40 | 2.41E-01 | 4.03E-01 |
| 17372662 | Proteoglycan 2, bone marrow | Prg2 | 0.41 | 2.81E-01 | 4.03E-01 |
| 17396152 | Carbonic anhydrase 3 | Car3 | 0.41 | 2.98E-01 | 4.03E-01 |
| 17424880 | Predicted gene, 19980 | Gm19980 | 0.41 | 1.01E-01 | 4.03E-01 |
| 17235011 | Elastase, neutrophil expressed | Elane | 0.41 | 3.23E-01 | 4.03E-01 |
| 17497704 | Cytochrome c oxidase, subunit VIIIb | Cox8b | 0.42 | 5.12E-02 | 4.03E-01 |
| 17232453 | Triadin | Trdn | 0.42 | 2.19E-01 | 4.03E-01 |
| 17246412 | Olfactory receptor 773 | Olfr773 | 0.42 | 2.52E-02 | 4.03E-01 |
| 17474621 | Creatine kinase, muscle | Ckm | 0.43 | 3.07E-01 | 4.03E-01 |
| 17243910 | Myosin binding protein C, slow-type | Mybpc1 | 0.43 | 2.22E-01 | 4.03E-01 |
| 17514553 | Matrix metallopeptidase 8 | Mmp8 | 0.44 | 3.49E-01 | 4.03E-01 |
| 17531482 | Cathelicidin antimicrobial peptide | Camp | 0.45 | 3.93E-01 | 4.11E-01 |
| 17438963 | Pro-platelet basic protein | Ppbp | 0.45 | 4.64E-01 | 4.64E-01 |
| 17284334 | Immunoglobulin heavy chain (gamma polypeptide) | Ighg | 0.45 | 1.68E-01 | 4.03E-01 |
| 17365803 | Nebulin-related anchoring protein | Nrap | 0.45 | 9.83E-02 | 4.03E-01 |
| 17490245 | Myosin binding protein C, fast-type | Mybpc2 | 0.45 | 1.72E-01 | 4.03E-01 |
| 17385099 | Nebulin | Neb | 0.46 | 1.73E-01 | 4.03E-01 |
| 17487759 | CD177 antigen | Cd177 | 0.46 | 2.38E-01 | 4.03E-01 |
| 17302279 | Olfactomedin 4 | Olfm4 | 0.46 | 2.44E-01 | 4.03E-01 |
| 17214476 | Desmin | Des | 0.47 | 1.84E-01 | 4.03E-01 |
| 17229851 | calsequestrin 1 | Casq1 | 0.47 | 1.23E-01 | 4.03E-01 |
| 17484587 | Cytochrome P450, family 2, subfamily e, polypeptide 1 | Cyp2e1 | 0.47 | 3.60E-01 | 4.03E-01 |
| 17294816 | Creatine kinase, mitochondrial 2 | Ckmt2 | 0.47 | 1.58E-01 | 4.03E-01 |
Note: The top 50 upregulated and downregulated genes at the 21-day time point after TIC injury are shown compared to the naïve control group with their p values and a false discovery rate of 5% (q value; n = 6 per group). TIC: trigeminal nerve injury. Bold font indicates genes uniquely expressed on Day 21 but not on Day 3.