Table 5.
Top 10 biological process and molecular function terms.
| Term | Count | p Value |
|---|---|---|
| Three days post-TIC injury-enriched “biological process” terms of differentially expressed genes | ||
| GO:0007399∼nervous system development | 44 | 4.38E-04 |
| GO:0045124∼regulation of bone resorption | 5 | 1.13E-03 |
| GO:0050790∼regulation of catalytic activity | 8 | 1.26E-03 |
| GO:0051262∼protein tetramerization | 10 | 1.31E-03 |
| GO:0007165∼signal transduction | 112 | 1.42E-03 |
| GO:0007264∼small GTPase mediated signal transduction | 29 | 2.32E-03 |
| GO:0016197∼endosomal transport | 9 | 3.18E-03 |
| GO:0051260∼protein homooligomerization | 25 | 3.27E-03 |
| GO:0000186∼activation of MAPKK activity | 8 | 3.76E-03 |
| GO:0034765∼regulation of ion transmembrane transport | 19 | 3.93E-03 |
| Three days post-TIC injury enriched "molecular function” terms of differentially expressed genes | ||
| GO:0043236∼laminin binding | 9 | 2.16E-04 |
| GO:0005216∼ion channel activity | 25 | 4.52E-04 |
| GO:0042803∼protein homodimerization activity | 79 | 5.48E-04 |
| GO:0005251∼delayed rectifier potassium channel activity | 9 | 1.01E-03 |
| GO:0071933∼Arp2/3 complex binding | 5 | 1.96E-03 |
| GO:0005244∼voltage-gated ion channel activity | 19 | 3.84E-03 |
| GO:0004871∼signal transducer activity | 62 | 4.93E-03 |
| GO:0051015∼actin filament binding | 18 | 7.43E-03 |
| GO:1901981∼phosphatidylinositol phosphate binding | 4 | 8.68E-03 |
| GO:0001664∼G-protein-coupled receptor binding | 11 | 1.00E-02 |
| 21 Days post-TIC injury enriched “biological process” terms of differentially expressed genes | ||
| GO:0048566∼embryonic digestive tract development | 6 | 1.15E-03 |
| GO:0016477∼cell migration | 20 | 1.65E-03 |
| GO:0007049∼cell cycle | 45 | 3.55E-03 |
| GO:0014044∼Schwann cell development | 4 | 9.63E-03 |
| GO:0007283∼spermatogenesis | 31 | 9.91E-03 |
| GO:0035458∼cellular response to interferon-beta | 7 | 1.16E-02 |
| GO:1902953∼positive regulation of ER to Golgi vesicle-mediated transport | 3 | 1.24E-02 |
| GO:0006364∼rRNA processing | 13 | 1.53E-02 |
| GO:0035457∼cellular response to interferon-alpha | 4 | 1.65E-02 |
| GO:0032868∼response to insulin | 9 | 1.77E-02 |
| 21 Days post-TIC injury enriched “molecular function” terms of differentially expressed genes | ||
| GO:0046872∼metal ion binding | 185 | 1.53E-02 |
| GO:0005525∼GTP binding | 29 | 1.59E-02 |
| GO:0003676∼nucleic acid binding | 76 | 1.67E-02 |
| GO:0005515∼protein binding | 219 | 2.62E-02 |
| GO:0046974∼histone methyltransferase activity (H3-K9 specific) | 3 | 2.97E-02 |
| GO:0043237∼laminin-1 binding | 3 | 2.97E-02 |
| GO:0003700∼transcription factor activity, sequence-specific DNA binding | 55 | 3.39E-02 |
| GO:0000977∼RNA polymerase II regulatory region sequence-specific DNA binding | 18 | 3.46E-02 |
| GO:0019789∼SUMO transferase activity | 4 | 3.76E-02 |
| GO:0004252∼serine-type endopeptidase activity | 17 | 4.56E-02 |
Note: Post-TIC injury differentially expressed genes at days 3 and 21 were enriched for the indicated processes and functions.