Table 3.
Comparison of clinical data of different genotypes of MTHFR C677T in the MetS group.
| CC | CT | TT | P value | |
|---|---|---|---|---|
| No. of cases | 134 | 310 | 207 | – |
| Sex (male/female) | 73/41 | 206/114 | 146/71 | 0.749 |
| Age (years) | 49.37 ± 10.17 | 49.90 ± 11.05 | 51.80 ± 10.55 | 0.067 |
| BMI (kg/m2) | 26.44 ± 2.53 | 26.86 ± 3.00 | 26.86 ± 3.20 | 0.333 |
| Waist circumference (cm) | 90.00 (84.00–95.00) | 91.00 (86.75–97.00)* | 91.00 (85.00–99.00)* | 0.026 |
| WHR | 0.89 ± 0.05 | 0.89 ± 0.05 | 0.90 ± 0.06*# | 0.017 |
| Systolic BP (mmHg) | 130.00 (114.00–134.00) | 135.00 (126.00–146.00)* | 138.00 (132.00–148.00)*# | <0.001 |
| Diastolic BP (mmHg) | 77.00 (68.00–84.00) | 82.00 (74.00–90.00)* | 86.00 (78.00–90.00)*# | <0.001 |
| FPG (mmol/L) | 5.40 (5.11–5.72) | 5.63 (5.19–6.12)* | 6.02 (5.34–7.27)*# | <0.001 |
| FINS | 7.53 (6.92–9.70) | 9.62 (7.25–12.91)* | 12.76 (8.98–15.60)*# | <0.001 |
| TG (mmol/L) | 1.89 (1.54–2.24) | 2.15 (1.52–2.90)* | 2.38 (1.78–3.33)*# | <0.001 |
| TC (mmol/L) | 4.76 ± 0.77 | 4.85 ± 0.99 | 4.99 ±1.10* | 0.095 |
| HDL-C (mmol/L) | 1.07 (0.94–1.21) | 1.03 (0.93–1.19) | 0.99 (0.86–1.19) | 0.011 |
| LDL-C (mmol/L) | 2.78 ± 0.67 | 2.82 ± 0.84 | 2.72 ± 0.87 | 0.392 |
| Hcy (µmol/L) | 10.55 (8.62–14.33) | 11.98 (10.54–13.27) | 15.62 (13.62–17.97)*# | <0.001 |
| HOMA-IR | 1.81 (1.55–2.46) | 2.37 (1.59–3.42)* | 3.44 (2.25–5.01)*# | <0.001 |
Values are mean ± SD or median (interquartile range).
*P < 0.05, compared with the CC genotype; #P < 0.05, compared with the CT genotype.
The Student–Newman–Keuls test was used for comparative analysis between the two groups.
MetS = metabolic syndrome; BMI = body mass index; WHR = waist-to-hip ratio; BP = blood pressure; FPG = fasting plasma glucose; FINS = fasting serum insulin; TG = triglycerides; TC = total cholesterol; HDL-C = high-density lipoprotein-cholesterol; LDL-C = low-density lipoprotein-cholesterol; Hcy = homocysteine; HOMA-IR = homeostasis model assessment of insulin resistance.