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. 2018 Jun 21;3(12):e98607. doi: 10.1172/jci.insight.98607

Figure 2. Chronic DHT excess predisposes female controls, but not βARKORIP mice, to diabetes.

Figure 2

Female mice were fed WD for 9 weeks followed by s.c. treatment with vehicle (V) or DHT for 4 weeks. (A) Fasting serum insulin levels. (B) Random fed serum insulin levels. (C) Insulin secretion during an i.p. glucose-stimulated insulin secretion (GSIS) test (3 g/kg) and corresponding AUC. (D) i.p. insulin tolerance test (ITT) with blood glucose represented as percentage decrease from baseline, with corresponding area under baseline (AUB). (E) β Cell mass and representative islets with insulin staining (green). Scale bar: 10 μm. (F) Islet area. (G) Pancreas insulin concentration. (H) Fasting blood glucose. (I) Random fed blood glucose. (J) Blood glucose during an i.p. glucose tolerance test (GTT) (2 g/kg) and AUC. (K) Hepatic pck1 relative expression quantified by qPCR. Values represent the mean ± SEM with dot plots (n = 6–19). *P < 0.05, **P < 0.01, Student’s t test or 2-way ANOVA.