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. 2018 Jun 21;3(12):e98607. doi: 10.1172/jci.insight.98607

Figure 4. Chronic DHT excess predisposes female controls, but not NARKO–/– mice, to diabetes.

Figure 4

ARlox/lox or NARKO–/– mice were fed WD for 9 weeks followed by s.c. treatment with vehicle (V) or DHT for 4 weeks. (A) Fasting serum insulin levels. (B) Fed serum insulin levels. (C) Blood glucose represented as percentage decrease from baseline during an i.p. insulin tolerance test (ITT), with corresponding area under baseline (AUB). (D) Fasting blood glucose. (E) Random fed blood glucose. (F) Blood glucose during an i.p. glucose tolerance test (GTT) and corresponding AUC. Values represent the mean ± SEM with dot plots (n = 4–15). *P < 0.05, **P < 0.01, ***P < 0.001, Student’s t test or 1-way or 2-way ANOVA.