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. 2018 Jun 7;3(11):e121000. doi: 10.1172/jci.insight.121000

Figure 2. Compound B reduces sodium currents in colon-innervating DRG neurons.

Figure 2

(A) Group data showing that sodium current density (pA/pF) in a population of colon-innervating DRG neurons was reduced when applying Compound B (100 μM). ****P < 0.0001, n = 14 neurons, paired t test. (B) Individual data from that the group data presented in A. ****P < 0.0001, n = 17 neurons, paired t test.(C) Compound B caused ~23% decrease in peak sodium currents in affected neurons (**P < 0.001, Mann Whitney U test). (D) Current-voltage (I-V) plots of sodium current density before (vehicle; black) and after (blue) Compound B application (100 μM) in inhibited colon-innervating DRG neurons. Data represent ± SEM.