Figure 1. Cam-003 peptide fusions bind to human and murine pIgR.
Binding of C-terminal peptide antibody fusions to pIgR was determined by ELISA. Cam-003 alone showed no binding to either human (A) or murine (B) pIgR at the highest concentration tested (200 μg/ml). Cam-003–QRN and its derivative Cam-003–KLKL had improved binding to pIgR compared with the natural pIgR ligand dimeric IgA, whereas another peptide fusion Cam-003–SAM exhibited poorer binding (n = 4). Data are representative of at least 2 independent experiments.