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. 2018 Jun 21;3(12):e120402. doi: 10.1172/jci.insight.120402

Figure 6. Imaging of classic neurofibroma and early indication of CNS-tumor formation in NF1+/ex42del miniswine model.

Figure 6

Neurofibromas on the neck of an 11-month-old male NF1+/ex42del mutant miniswine (green and yellow indicate separate lesions) (A) and a volumetric reconstruction from the MRI data (B). The lesion (yellow arrow) is iso-intense to muscle on T1-weighted MRI (axial view; C) and demonstrates a central hypo-intense region on T2 weighted MRI (axial view; D) and minimal contrast enhancement (data not shown). An 11-month-old male NF1 mutant with poor cognitive scoring through behavioral testing had a radiological finding in the brain. The axial orientation (E–H) and corresponding sagittal view (I–L) are shown. A cerebellar region of hyper-intensity is evident on a fluid attenuation inversion recovery (FLAIR) MRI (F and J) (highlighted by yellow arrow). This finding was less evident on T2-weighted MRI without fluid suppression (G and K), and it was not evident on T1-weighted MRI (H and L).