Table 1.
Characters of included studies
| Study source | Study design | Study population | Gender (m/f) | Number of participants | COPD diagnosis | FENO measurement |
|---|---|---|---|---|---|---|
| Kanazawa et al,16 1998 | CS | Japan | 21/0 | 21 | ATS | Chemiluminescence analyzer (CLM-500; Shimazu; Kyoto, Japan) |
| Rutgers et al,23 1998 | CS | the Netherlands | 25/7 | 32 | Doctor-diagnosis | Chemiluminescence analyzer (CLD 700 AL, ECO physics, Dürnten, Switzerland) |
| Agusti et al,29 1999 | CS | Spain | 27/0 | 27 | Doctor-diagnosis | Chemiluminescence analyzer (Dasibi Environmental, Glendale, CA, USA) |
| Corradi et al,28 1999 | CS | Italy | 32/18 | 50 | BTS | Chemiluminescence NO analyzer (model 42S; Thermo Environmental Instruments Inc, Franklin, MA, USA) |
| Clini et al,11 2000 | CS | Italy | 17/2 | 19 | ATS | Chemiluminescence analyzer (LR 2000 series; Logan Research; Kent, UK) |
| Delen et al,13 2000 | CS | America | NA | 77 | Doctor-diagnosis | Chemiluminescence (model 280; Sievers Instruments; Boulder, CO, USA) |
| Papi et al,20 2000 | CS | Italy | 24/5 | 29 | ERS | Chemiluminescence analyzer (NOA 280; Sievers) |
| Montuschi et al,19 2001 | CS | United Kingdom | 27/25 | 52 | BTS | Chemiluminescence analyzer (model LR 2000; Logan Research; Rochester, UK) |
| Hogman et al,15 2002 | CS | Sweden | NA | 60 | Doctor-diagnosis | 280 chemiluminescence analyzer (Sievers) |
| Zietkowski et al,27 2005 | CS | Poland | 58/29 | 87 | ERS | Chemiluminescence technique (Sievers 280i NO analyzer, Sievers) |
| Brindicci et al,10 2005 | CS | United Kingdom | 27/24 | 51 | GOLD | Chemiluminescence analyzer (NIOXH; Aerocrine AB, Stockholm, Sweden) |
| Ziora et al,26 2007 | CS | Poland | 51/12 | 63 | GOLD | Chemiluminescent NO analyzer (model 280, Sievers Instruments) |
| Liu et al,17 2007 | CS | Australia | NA | 176 | Doctor-diagnosis | Chemiluminescent NO analyzer (Dasibi Environmental Corp.) |
| de Laurentiis et al,12 2008 | CS | Italy | NA | 69 | GOLD | Electrochemical FENO device (NIOX MINO, Aerocrine)/chemiluminescence analyzer (NOA, Sensormedics, Milano, Italy) |
| Beg et al,31 2009 | CS | Saudi Arabia | 39/0 | 39 | Doctor-diagnosis | Chemiluminescence analyzer (SERES, Aix-en-Provence, France) |
| Lehouck et al,33 2010 | CC | Belgium | 121/30 | 151 | GOLD | Chemiluminescence analyzer (NIOX, Flex; Aerocrine AB) |
| Rouhos et al,22 2011 | CS | Finland | 18/21 | 39 | Doctor-diagnosis | Chemiluminescence analyzer (Sievers 270B, Sievers) |
| Maricic et al,18 2013 | CS | Croatia | NA | 100 | GOLD | NA |
| Sun et al,25 2013 | CS | People’s Republic of China | 35/10 | 45 | CMA | The 4540-1999b portable nitric oxide gas detector (Interscan Corporation, Simi Valley, CA USA) |
| Hirano et al,14 2013 | CS | Japan | 24/12 | 36 | GOLD | Chemiluminescence-based NO analyzer NA-623N, (Chest Co. and Kimoto Electric Co., Tokyo, Japan) |
| Moussa et al,32 2014 | CC | Tunisia | 45/0 | 45 | Doctor-diagnosis | Electrochemical analyzer (Medisoft, Dinant, Belgium) |
| Rawy and Mansour,21 2015 | CS | Egypt | 61/29 | 90 | Doctor-diagnosis | Niox Mino analyzer (Aerocrine AG) |
| Santini et al,30 2016 | CS | Italy | 67/22 | 99 | GOLD | NIOX system (Aerocrine) |
| Shrestha et al,24 2017 | CS | Nepal | 91/121 | 212 | GOLD | Handheld Bedfont NO breath point-of-care device (Bedfont Scientific Ltd, Maidstone, Kent, UK, registered in England and Wales) |
Abbreviations: ATS, American Thoracic Society criteria; BTS, British Thoracic Society guidelines; CC, case–control study; CMA, Chinese Medical Association guidelines; COPD, chronic obstructive pulmonary disease; CS, cross-sectional study; ERS, European Respiratory Society criteria; FENO, fractional exhaled nitric oxide; GOLD, Global Initiative for Obstructive Lung Disease; NA, not available.